BRD4 and neoplasm: Importantly, when we compared these genes with those downregulated after JQ1 treatment in UM-SCC-047 (n = 1,243), we discovered a significant negative correlation between tumor-specific gene expression (Log2FC[T/N]) and BRD4 inhibition (Log2FC[JQ1/DMSO]) (R = −0.28, p = 1e-06) (Figure S1A).