Nonsense mutation in the highly conserved fmr1 gene, the silencing of which causes Fragile X syndrome (FXS) in humans, leads to decreased habituation toward visual stimuli in larvae, replicating a behavioral phenotype in human patients with FXS (Marquez-Legorreta et al., 2022; Constantin et al., 2020; Ethridge et al., 2016). This evidence concerns the gene FMR1 and fragile X syndrome.