Among focal epilepsies, temporal lobe epilepsy is recorded to have a significant impact on GnRH pulsatility by causing disruptions to the HPG axis, where right sided temporal foci are associated with hypogonadotropic hypogonadism causing reduced gonadotropin secretion, while left-sided temporal foci are associated with hyperandrogenic and PCOS causing increased LH to FSH ratios and chronic anovulation (48, 49). Here, PLOD1 is linked to focal epilepsy.