Compared to the bilayer mats group, the PLCL group exhibited a significant up-regulation of genes related to atherosclerosis and inflammation, such as TNF, CXCL2, and IL6, suggesting that the PLCL/KSN//PLCL/SCC group had a positive effect on lipid metabolism and anti-inflammation through the release of NO and H2S (Fig. 5c). The gene discussed is CXCL2; the disease is atherosclerosis.