The results showed that LW regulated the AGE-RAGE signaling pathway in diabetic complications and the TGF-beta signaling pathway by targeting VEGFA, EGR1 and BMP4 through ingredients taxifolin, cianidanol, gallic acid, caffeic acid, 5-hydroxymethylfurfural and paeonol, thereby ameliorating glomerular microvascular injury and renal fibrosis (Fig. 10). This evidence concerns the gene EGR1 and renal fibrosis.