In scenario A, we will include the yearly cost of 2 doses of adrenaline, 1 visit without a subsequent stay in the emergency room, 3 allergy visits, a dietary visit, a battery of diagnostic procedures including skin testing, molecular diagnostics, specific IgE and 1 oral provocation tests, 2 visits to the general practitioner, and 1 visit to the psychologist. This evidence concerns the gene IGHE and allergic disease.