SERPING1 and hereditary angioedema: While these data suggest that PKa activity is increased in these patients compared with controls without HAE, longitudinal studies on a larger and fully characterized cohort of HAE-C1INH and HAE-nC1INH patients that are adequately powered to detect differences in PKa activity compared with controls are needed to evaluate the potential of this assay as a biomarker and to evaluate intra-individual variability.