In addition to establishing DGKH as a pivotal driver of HCC stemness and TKIs resistance, they delineated a DGKH-phosphatidic acid (PA)-mammalian target of rapamycin (mTOR) signaling axis and demonstrated that E1A-associated protein p300 (EP300) transcriptionally up-regulates DGKH expression. This evidence concerns the gene MTOR and hepatocellular carcinoma.