Negative SATB2 staining with MUC4 positivity has also been shown to be a valuable marker in the diagnosis of SEF as opposed to osteosarcoma [5,11,12]. In our review of the 24 cases that tested for both, 16 cases stained both positive for MUC4 and negative for SATB2. Here, SATB2 is linked to osteosarcoma.