These mechanisms include protein misfolding and aggregation (amyloid-β plaques and tau tangles in Alzheimer’s disease and α-synuclein aggregates in Parkinson’s disease), oxidative stress and mitochondrial dysfunction, neuroinflammation, vascular insufficiency leading to ischemic damage, autoimmune-mediated demyelination (multiple sclerosis, MS), and progressive motor neuron degeneration (amyotrophic lateral sclerosis) [14,15]. Here, SNCA is linked to Parkinson disease.