Anti-Jo-1 Ab: anti-histidyl-tRNA synthetase antibody; anti-SRP Ab: anti-signal recognition particle antibody; CN-1A Ab: anti-cytosolic 5'-nucleotidase 1A antibody; ANA: antinuclear antibody; ANCA: antineutrophil cytoplasmic antibody; RF: rheumatoid factor; MPO Ab: myeloperoxidase antibody; PR3 Ab: proteinase 3 antibody; anti-dsDNA: anti-double-stranded DNA antibody; CREST: calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, and telangiectasia. The gene discussed is PRTN3; the disease is telangiectasis.