A similar pattern of increased exosomal PD-L1 has been reported in OSCC and other HNSCCs. Plasma-derived exosomes carrying high levels of PD-L1, which are called PD-L1+, were significantly elevated in HNSCC patients with active disease, advanced tumor stage, and lymph node metastasis. The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.