GSDMD and periodontitis: Salivary exosomal miR-223-3p was significantly downregulated in periodontitis. Inhibition of miR-223-3p increased inflammatory and pyroptosis markers (NLRP3, caspase-1, GSDMD, IL-1β, IL-6) in macrophages. NLRP3 and GSDMD-N were upregulated in periodontitis gingival tissue.