Angiosarcomas are genetically heterogeneous, and most tumors harbor complex karyotypes including trisomy of the 5th chromosome and loss of Y chromosome, KDR (knockdown resistance) mutations, PTPRB (gene encoding protein tyrosine phosphatase, receptor type B), PLCG1 (gene encoding phospholipase C gamma 1), and a novel fusion gene in the NUP160-SLC43A3 [5]. Here, PTPRB is linked to angiosarcoma.