A 38-year-old male with a BMI of 23 and a history of chronic low back pain, prior L5-S1 fusion, migraines, obstructive sleep apnea (OSA), chronic obstructive pulmonary disease (COPD), Factor V Leiden mutation (not on anticoagulation), and active tobacco use, presented to our emergency department with right-sided posterior back and lung pain. The gene discussed is F5; the disease is chronic obstructive pulmonary disease.