Among them, the adverse reactions that showed significant differences in patient information, blood laboratory values, PNI, SIRI, or inflammatory indices between the Grade 0 and Grade ≥ 1 groups at the beginning of one cycle were: peripheral neuropathy, hand-foot syndrome, nausea, anorexia, diarrhea, leukopenia, neutropenia, Hb decreased, and thrombocytopenia. The gene discussed is GSTM1; the disease is peripheral neuropathy.