The patient met five out of eight HLH-2004 diagnostic criteria (Table 1), including high ferritin level, splenomegaly, elevated soluble CD25 levels, low NK cell activity, and hemophagocytosis confirmed on bone marrow biopsy, so he was initiated on high-dose dexamethasone with a tapering regimen. Here, IL2RA is linked to Hemophagocytosis.