IL6 and Flavivirus Infections: IL-6, a pro-inflammatory cytokine, is a keymediator in the immune response and exerts significant effects onvascular function and coagulation pathways., Elevated IL-6 levels during flavivirus infections have been implicatedin endothelial activation, promoting the expression of adhesion moleculesand the recruitment of immune cells, which may exacerbate vascularleakage.