Elevated IL-6 levels can amplify TF expression,contributing to a hypercoagulable state that is commonly observedin severe flavivirus infections., Moreover,significantly higher levels of MVs and IL-6 were reported to associatewith coagulopathy due to viral infections, as observed in COVID-19patients. Based on this, we examinedthe influence of sNS1 proteins on IL-6 secretion by monocytes as amarker of inflammatory induction. The gene discussed is TF; the disease is viral infectious disease.