VEGFA and endothelial dysfunction: Moreover, docetaxel also inhibited the phosphorylation of focal adhesion kinase (FAK) and the activation of integrin αVβ3, two molecules that together with vascular endothelial growth factor receptor-2 (VEGFR-2) form a complex responsible for VEGF signal transduction by Akt phosphorylation, leading to significant reduction in eNOS phosphorylation and bioavailable NO production, thus resulting in endothelial dysfunction (103).