Moreover, docetaxel also inhibited the phosphorylation of focal adhesion kinase (FAK) and the activation of integrin αVβ3, two molecules that together with vascular endothelial growth factor receptor-2 (VEGFR-2) form a complex responsible for VEGF signal transduction by Akt phosphorylation, leading to significant reduction in eNOS phosphorylation and bioavailable NO production, thus resulting in endothelial dysfunction (103). Here, NOS3 is linked to endothelial dysfunction.