Fan Feng et al.(2024) found that lactylation of the K230/322 site of aldolase A (ALDOA) in hepatocellular carcinoma stem cells (LCSCs) attenuates its binding to DDX17, which promotes the entry of DDX17 into the nucleus, enhances the stemness characteristics of LCSCs, and then exacerbates the development of hepatocellular carcinoma. Here, DDX17 is linked to hepatocellular carcinoma.