Functional experiments showed that knocking down DDX17 can completely reverse the carcinogenic phenotype induced by overexpression of SNHG20, and high expression of SNHG20 is significantly associated with high Gleason score (>7) and advanced tumor stage (≥T2c) in prostate cancer, suggesting that the function of DDX17 regulated by SNHG20 plays a role in carcinogenesis (43). The gene discussed is DDX17; the disease is Familial prostate cancer.