In a variety of cancers, such as colon, breast, prostate, non-small cell lung, glioma, and hepatocellular carcinoma, DDX17 promotes cancer cell proliferation and inhibits apoptosis through the activation or inhibition of specific signaling pathways, thereby promoting tumorigenesis and progression (Figure 2) (21, 22, 29, 30). The gene discussed is DDX17; the disease is hepatocellular carcinoma.