In a variety of cancers, such as colon, breast, prostate, non-small cell lung, glioma, and hepatocellular carcinoma, DDX17 promotes cancer cell proliferation and inhibits apoptosis through the activation or inhibition of specific signaling pathways, thereby promoting tumorigenesis and progression (Figure 2) (21, 22, 29, 30). This evidence concerns the gene DDX17 and glioma.