Secondly, insulin can further cause lipid hyaluronic acid degeneration by enhancing sympathetic nerve activity or acting as a growth factor, and lipophosphate deposition can block small arteries, leading to the occurrence of CVD (35); IR can induce glucose metabolism disorders and lipotoxicity, and may also lead to the inactivation of nitric oxide and the excessive production of reactive oxygen species, resulting in the inflammation and dysfunction of vascular endothelium, resulting in the occurrence of a variety of chronic diseases (35). Here, INS is linked to glucose metabolism disease.