METTL16, an independent m6A methyltransferase, has recently been found to be widely involved in the regulation of multiple cancers, including lung cancer (LC), Hepatocellular carcinoma(HCC), Colorectal Cancer (CRC), Acute Myeloid Leukemia (AML), Ovarian Cancer (OV),Gastric Cancer (GC), Pancreatic Adenocarcinoma (PAAD), Breast Cancer, Cholangiocarcinoma (CCA) and Bladder Cancer (BLCA) (Figure 2 and Figure 3). Here, METTL16 is linked to laryngotracheoesophageal cleft.