METTL16, an independent m6A methyltransferase, has recently been found to be widely involved in the regulation of multiple cancers, including lung cancer (LC), Hepatocellular carcinoma(HCC), Colorectal Cancer (CRC), Acute Myeloid Leukemia (AML), Ovarian Cancer (OV),Gastric Cancer (GC), Pancreatic Adenocarcinoma (PAAD), Breast Cancer, Cholangiocarcinoma (CCA) and Bladder Cancer (BLCA) (Figure 2 and Figure 3). This evidence concerns the gene METTL16 and pancreatic adenocarcinoma.