METTL16, an independent m6A methyltransferase, has recently been found to be widely involved in the regulation of multiple cancers, including lung cancer (LC), Hepatocellular carcinoma(HCC), Colorectal Cancer (CRC), Acute Myeloid Leukemia (AML), Ovarian Cancer (OV),Gastric Cancer (GC), Pancreatic Adenocarcinoma (PAAD), Breast Cancer, Cholangiocarcinoma (CCA) and Bladder Cancer (BLCA) (Figure 2 and Figure 3). The gene discussed is METTL16; the disease is bladder transitional cell carcinoma.