Importantly, we found a significant positive correlation between GINS2 mRNA expression levels (potentially from bulk tumor or sorted tumor cells) and the PD-L1 MFI on associated neutrophils (r=0.7885, P<0.001; n = 15 matched OSCC cases; Figure 6a, right panel), suggesting GINS2 expression levels influence the immunosuppressive phenotype of TANs. This evidence concerns the gene CD274 and neoplasm.