Specifically, GINS2 (Psf2) overexpression has been reported in various human malignancies, including head and neck squamous cell carcinomas (HNSCC) (11), epithelial ovarian cancer (12), Osteosarcoma (13), cervical cancer (14), often correlating with aggressive tumor characteristics and poor patient prognosis. The gene discussed is GINS2; the disease is head and neck squamous cell carcinoma.