TLR8 and nervous system disorder: Given the growing interest in TLRs and miRNAs as potential therapeutic targets and tools, especially in neurological disease (49–56), alongside the expanding research on miRNA-induced TLR activation observed in murine models, and the noteworthy interspecies differences between murine and human TLRs (16, 18, 27, 30), we addressed the question of whether miRNAs can act as ligands for TLR7 and TLR8 in human microglia.