We then assessed whether selected miRNAs, which i) based on their sequence and structure have been previously predicted as potent hTLR7 and/or hTLR8 activators by the algorithm Braindead, ii) have been validated as ligands for these RNA sensors, and iii) whose expression is specifically dysregulated in AD and glioma, can act as extracellular ligands, thereby altering iMGL function. Here, TLR8 is linked to glioma.