Alzheimer’s disease (AD), identified as the predominant form of dementia in the elderly population, is characterized by the accumulation of extracellular amyloid-beta (Aβ) plaques and the formation of neurofibrillary tangles (NFTs), which result from the hyperphosphorylation of tau protein (Scheltens et al., 2021). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.