TP53 and glioblastoma: The mutational profiles of early-onset and late-onset GBM are displayed in Figure 1B. The most frequently mutated genes in early-onset GBM are TERT (45.5%), TP53 (37.3%), and EGFR (27.3%), whereas in late-onset GBM, the most mutated genes are TERT (84.4%), EGFR (42.9%), and PTEN (36.7%; Fig. 1B).