EZH2 and triple-negative breast carcinoma: In triple-negative breast cancer, curcumin is noted to reinstate the expression of the tumor suppressor DLC1 by restricting the oncogene Enhancer of zeste homolog 2 (EZH2) through the reduction of Histone 3 lysine 27 trimethylation (H3K27me3) enrichment in the DLC1 promoter, consequently inhibiting the proliferation, migration, and invasion of TNBC cells while achieving apoptosis (Zhou X. et al., 2020).