PTEN and cancer: Studies detected that dietary factors such as curcumin have appropriate anti-cancer properties (Mirzaei et al., 2016a); moreover, the exerted agents are influenced by a multiple of molecular and cellular pathways such as Mitogen-activated protein kinases (MAPK), Phosphatase and Tensin Homolog deleted on chromosome 10 (PTEN), signal transducer and activator of transcription (STAT), and a network of miRNA (Figure 6).