Importantly, curcumin demonstrates a multifaceted epigenetic influence that encompasses the inhibition of DNA methyltransferases leading to DNA demethylation and reactivation of silenced tumor-suppressor genes, modulation of histone acetylation and methylation balance to restore normal chromatin accessibility, regulation of non-coding RNAs such as microRNAs, lncRNAs, and circRNAs that control gene expression, and alteration of RNA methylation (m6A modification) through modulation of METTL3, FTO, and YTHDF proteins, which influence mRNA stability and translation efficiency. The gene discussed is METTL3; the disease is neoplasm.