NOS2 and ischemic stroke: Baicalin also suppresses pro-inflammatory enzymes, including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in MCAO rat models (Zhang Q. et al., 2017), both of which are strongly associated with inflammatory responses in ischemic stroke (Li T. et al., 2022; Li L. et al., 2021).