Studies have shown that dopamine neurons lack degeneration, neuroinflammation, mitochondrial dysfunction and oxidative stress are the characteristics of its pathogenesis, and PNS can alleviate dopamine neuron damage and apoptosis through P2Y2R/PI3K/AKT/NF-κB and IGF-I signaling pathways by exerting anti-inflammatory and antioxidant effects, as well as through the autophagy process mediated by PINK1 and PARKIN to effectively ameliorate PD. Here, AKT1 is linked to Parkinson disease.