Multiple saponins isolated from the aqueous extract of Panax quinquefolium exerted neuroprotective effects on damaged human neuroblastoma (SH-SY5Y) cells (Liu et al., 2018), Suppressing the overexpression of NgR1/RhoA/ROCK2 by modulating the myelin-associated inhibitory molecule, Nogo-A, in vivo and in vitro in the rat model of cerebral ischemia and in the rat model of exposure to OGD/R injury in the SH-SY5Y cell model providing neuroprotection (Shi et al., 2016). Here, RHOA is linked to brain ischemia.