The protective properties could also be enhanced by increasing the activities of antioxidant enzymes, which significantly increased the activities of antioxidant enzymes (including SOD, GSH-PX, and CAT) in SAMP8 mice and B16 melanoma cells by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway, and simultaneously decreased the oxidative damage markers, 8-hydroxylated deoxyguanosine (8-OHdG) levels. This evidence concerns the gene HMOX1 and melanoma.