R2 is able to inhibit apoptosis through the miR-27a/SOX8/β-catenin axis expression, attenuate Aβ25-35-triggered neuronal apoptosis and inflammation, and inhibit cortical neuronal apoptosis and attenuate inflammation in AD rats as a way to enhance cognitive function and improve AD symptoms in AD rats (Hu et al., 2021); It can also prevent isoflurane-induced learning and cognitive impairments by promoting miR-29a expression and preventing inflammatory responses (Wang et al., 2022). Here, SOX8 is linked to Alzheimer disease.