NAMPT and ischemia: By regulating the Notch signaling pathway to activate the nicotinamide phosphoribosyltransferase-nicotinamide adenine dinucleotide-Sirtuin 1 (NAMPT-NAD+-SIRT1) cascade reaction, this approach promotes angiogenesis following stroke-induced ischemia, thereby improving vascular cognitive impairment and dementia (Zhu et al., 2021b).