The expression of placental P-gp and BCRP was measured by RT-PCR and Western blot techniques in schizophrenia-like Wisket and control Wistar rats on gestation days 15, 18, 20, 21, and 22, while the histone acetyltransferase activity and global methylation state of the placenta were detected by colorimetric kits. This evidence concerns the gene PGP and schizophrenia.