These data support that inhibition of SIRT7 prevents the downregulation of RELA acetylation, and thus prevents fibrogenesis in livers of largemouth bass induced by HCHFD suggesting that the SIRT7-RELA regulatory axis may represent a potential target for prevention and treatment of liver fibrosis in fish (Fig. 12). The gene discussed is SIRT7; the disease is Hepatic fibrosis.