As neuroinflammation emerges as a cornerstone of delirium pathogenesis, this work forces us to confront a critical question: Could AID represent the “missing link” explaining heterogeneity in delirium susceptibility beyond traditional risk factors? Their findings challenge the prevailing clinical paradigm that primarily focuses on acute insults, urging a shift toward integrating chronic immune dysregulation into delirium risk models. Here, AICDA is linked to delirium.