Specifically, we aimed to: (i) investigate temporal modelling for plasma p-tau217, (ii) characterize the timing of 11C-PiB amyloid PET onset and plasma p-tau217 onset relative to each other; (iii) examine associations between the timing of amyloid PET and plasma p-tau217 with tau PET accumulation, and (iv) investigate associations between the timing of amyloid PET and plasma p-tau217 onset with preclinical cognitive decline. Here, MAPT is linked to Mental deterioration.