MAPT and early-onset autosomal dominant Alzheimer disease: Our group and others have recently developed and validated temporal modelling methods that enable person-level estimates of amyloid plaque onset age ascertained from amyloid PET imaging.13-16 These methods and this biomarker clock framework provide a way to visualize and study the timing of key Alzheimer’s disease events, such as beta-amyloid plaque and tau tangle deposition, on an individual person level.