,28,48 APC function can be evaluated by their ability to (1) phagocytose tumor cells, (2) express co-stimulatory markers that support T cell activation, (3) secrete T cell activating cytokines, and (4) present antigen via major histocompatibility complex (MHC) class I and MHC class II to T cells.49 This evidence concerns the gene HLA-C and neoplasm.