Our RNA-Seq data uncovered the enrichment of Wnt/β-catenin signaling in association with ABTB2 dysregulation, and previous studies have demonstrated that aberrant activation of Wnt/β-catenin signaling is tightly linked to cancer development and progression through the abnormal expression of cyclin D1/D3, CDK4, and CDK6.55 Here, CDK4 is linked to cancer.