The microenvironment of tumor seeded with V583 demonstrated increased density of CD4+ (49.85 vs 16.46 cells/mm2, p = 0.02 unpaired t-test) and CD4 + FoxP3+ (4.85 vs 1.81 cells/mm2, p = 0.04) cells in the tumor microenvironment. The gene discussed is CD4; the disease is neoplasm.