In contrast, Smed-YTHDF2-2 RNAi alone did not result in spermatogenesis defects (Fig. 6G-G’ and 6I), but did increase the penetrance of the azoospermia to 100 % of samples when combined with Smed-METTL3;Smed-METTL14 RNAi (Fig. 6H-H’ and 6I). This evidence concerns the gene METTL3 and Azoospermia.