Using the CIBERSORT deconvolution algorithm on RNA‐seq profiles of primary HCC tumors from the Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA‐LIHC) cohort, we found that YY1‐low tumors exhibited a significantly higher proportion of CD8+ cytotoxic T cells than YY1‐high tumors (Figure 2A). Here, YY1 is linked to hepatocellular carcinoma.