In the tumor cell‐CD8+ T cell coculture system, genetic rescue experiments demonstrated functional restoration of CD8+ T cell activity: knocking down GALNT16 in YY1‐overexpressing tumor cells (Figure 4D) or overexpressing GALNT16 in YY1‐knockdown cells (Figure 4E, F) both reversed YY1‐mediated CD8+ T cell impairment. This evidence concerns the gene CD8A and neoplasm.