ORAOV1 expression was significantly positively correlated with infiltration of regulatory T cells (Tregs) (Knochelmann et al., 2018; Noack & Miossec, 2014), myeloid-derived suppressor cells (MDSCs) (Gomez et al., 2020; Wesolowski, Markowitz & Carson 3rd, 2013), and cancer associated fibroblast cells (CAFs) (Affo, Yu & Schwabe, 2017) (p < 0.05) , but not with tumor purity (p = 0.0526) (Fig. 5A). This evidence concerns the gene LTO1 and neoplasm.