Using the GEPIA2 database (http://gepia2.cancer-pku.cn/#index) and Spearman correlation (|r| > 0.1, p < 0.05) (Tang et al., 2019), ORAOV1 expression was found to be positively correlated with 26 immune checkpoint genes, including CTLA4, PD1, and PD-L1 (Fig. 5B), all of which are commonly targeted in immunotherapies for HCC (Sangro et al., 2021; Topalian, 2017; Topalian et al., 2016) (Fig. 5B). The gene discussed is CTLA4; the disease is hepatocellular carcinoma.