Among these, CCND1, IGHMBP2, and TPCN2 are co-located with ORAOV1 within the frequently amplified 11q13 chromosomal region (Grohmann et al., 2001; Huang et al., 2002; Khan et al., 2007), which has been implicated in HCC pathogenesis (Zhai et al., 2014; Zucman-Rossi et al., 2015). This evidence concerns the gene LTO1 and hepatocellular carcinoma.