MAGEL2 and obesity due to melanocortin 4 receptor deficiency: More importantly, we also demonstrated that deleting the Magel2 gene exclusively in ARCPomc neurons that project to the MeA inhibited the onset of diet-induced obesity (DIO) in both male and female mice during a high-fat diet (HFD) feeding, which seems to be linked to an increase in physical activity (Choi et al., 2022).