However, about 2–5% of the BA escape absorption in the small intestine and enter the hindgut, where they are metabolised by the gut microbiota.(2) BA, besides their crucial role in fat digestion and lipid absorption, are important signalling molecules for the digestive function, cell proliferation, cancer promotion and the immune system.(3,4) The link between BA and signalling through farnesoid X receptor (FXR) and takeda G protein-coupled receptor 5 (TGR5) is integral to the regulation of BA synthesis, enterohepatic circulation, and associated metabolic processes. This evidence concerns the gene NR1H4 and cancer.