In hepatocytes, Liao et al. (68) identified upregulation of Cytochrome P450-2E1 (CYP2E1) and nuclear translocation of sterol regulatory element-binding protein 1 (SREBP1) as critical mechanisms underlying PA-induced ferroptosis, contributing to metabolic dysfunction-associated fatty liver disease (MAFLD). This evidence concerns the gene CYP2E1 and fatty liver disease.