GPX4 and osteoarthritis: In alignment with our findings, He et al. (78) reported that α-KG markedly attenuates osteoarthritis progression by reducing cartilage matrix degradation and apoptosis, suppressing ROS, MDA, and ferrous ion accumulation, enhancing SOD activity and the GSH/GSSG ratio, preserving MMP stability, and upregulating ETV4, SLC7A11, and GPX4.