After controlling for hematocrit, total protein, phosphorus, globulin, and albumin, the direct effects remained largely unchanged: intestinal obstruction (2.3-fold increase, p < 0.001), impaction (2.6-fold increase, p < 0.001), and diarrhea (3.0-fold increase, p < 0.001). The gene discussed is ALB; the disease is intestinal obstruction.