HLA-E and Infertility: First, a male-specific signal has been reported in Euro-Brazilian ART couples, HLA-E*01:03 homozygosity was more common among male partners of infertile couples, while no significant association was detected among women in the same cohort, suggesting a possible contribution of HLA-E to male subfertility that requires replication in other populations (Gelmini et al., 2016).