It is important to recognize that the negative impact of obesity on women’s reproductive health extends beyond disruptions in the HPO axis; it is also associated with various pregnancy complications and adverse outcomes (Schon et al., 2024), including higher rates of miscarriage and poorer outcomes in assisted reproductive technologies like in vitro fertilization (IVF) (Klenov and Jungheim, 2014). The gene discussed is GFER; the disease is obesity disorder.