These findings align with the conclusions drawn from studies using laser capture microdissection and RNA sequencing to investigate the characteristics of the primordial to primary follicle transition in obese mice, which suggest that obesity may accelerate primordial follicle pool depletion and decline in ovarian reserve function through excessive activation of mTOR signaling (Zhou et al., 2023). The gene discussed is MTOR; the disease is obesity due to melanocortin 4 receptor deficiency.