Interest in the involvement of NKA in a hereditary form of retinal dystrophy, X-linked juvenile retinoschisis (XLRS), was fostered after discovering that the deficient protein in the disease, retinoschisin, directly interacts with the retinal NKA α3β2 isoenzyme (Molday et al., 2007). Here, TAC1 is linked to X-linked retinoschisis.