TTR and hypertensive disorder: Increased circulating concentration of CTS have been reported both in rodent models with volume expansion and high blood pressure and in patients with essential hypertension (Hamlyn et al., 1982; Ferrandi et al., 1992; Yamada et al., 1994; Huang and Leenen, 1998; Manunta et al., 2001; Manunta et al., 2005; Fedorova et al., 2010).