Under metabolic stress conditions, such as obesity and hyperglycemia, these macrophages can be activated through receptors such as TLR4 and RAGE, triggering the NF-κB and NLRP3 inflammasome signaling pathways and promoting the release of pro-inflammatory cytokines such as IL-1β and TNF-α [33]. The gene discussed is NLRP3; the disease is Hyperglycemia.