By suppressing MMP-2 and MMP-9 activity in HCT116 cells (human colorectal adenocarcinoma), SK-MEL-5 cells (malignant melanoma), and MDA-MB-231 cells (breast adenocarcinoma), laminaran sulphate, which is extracted from the brown alga Fucus evanescens, was shown to be an effective anti-migratory drug [88,89]. This evidence concerns the gene MMP2 and melanoma.