In another pioneering research, Malyarenko et al. [90] showed that sulphated laminaran, extracted from the brown alga Dictyota dichotoma (Desfontaines) J.V. Lamouroux, may modulate the function of MMP-2 and MMP-9, thereby enhancing the effect of X-rays and stopping the migration of SK-MEL-28 melanoma cells. This evidence concerns the gene MMP2 and melanoma.