Therapeutically, modulating ZMIZ1 function may restore hormonal responsiveness in conditions such as endometriosis, whereas inhibition of ZMIZ1 could suppress estrogen-driven proliferation in malignancy, supported by Hewitt et al.’s finding that siZMIZ1 reduced proliferation in Ishikawa endometrial cancer cells (1). The gene discussed is ZMIZ1; the disease is endometriosis.