The trend towards decreased expression of ZMIZ1 transcript in endometriosis versus normal eutopic endometrium, together with our observation that targeting uterine ZMIZ1 impairs PGR expression, suggests that ZMIZ1 may impact development of endometriosis by contributing to progesterone resistance, and future work to examine this possible mechanism might yield endometriosis therapies that target ZMIZ1. Here, ZMIZ1 is linked to endometriosis.