The expression and biological roles of ZMIZ1 have not been previously characterized in nondiseased uterine tissue; however, its location at an ESR1-binding super enhancer (14), and interaction with hormone receptors, AR in prostate cancer cells (27), and ESR1 in breast cancer cells, prompted consideration of potential roles for ZMIZ1 in endometrial health. Here, ESR1 is linked to breast carcinoma.