Beyond E-cadherin, we observed enrichment of proteins that preferentially associate with nonpalmitoylated CTNND1, including filaggrin (FLG), plakophilin-1 (PKP1), and transglutaminase 1 (TGM1), all linked to poor clinical outcomes in metastatic melanoma (66). The gene discussed is CTNND1; the disease is metastatic melanoma.