CD4 and melanoma: Our results indicated that ZDHHC13 in B16 cells notably increased the proportion of M1-like TAMs (Figure 6, F and G), CD8+ (Supplemental Figure 12C), CD4+ (Supplemental Figure 12D), and NK cells (Supplemental Figure 12E), while diminishing the population of M2-like TAMs in subcutaneously inoculated tumors as well as in tail vain injection–induced melanoma lung metastasis (Figure 6, F and G).